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    blog address: https://cmiresearch.blogspot.com/2021/08/angiogenesis-invasion-and-migration-of.html

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    member since: Aug 9, 2021 | Viewed: 643

    Angiogenesis, invasion, and migration of tumor cells can be inhibited by antithrombin

    Category: Health

    Antithrombin is an important inhibitor of the coagulation cascade, but it can also serve as an anti-inflammatory, antiangiogenic, antiviral, and antiapoptotic protein. A role for antithrombin in modulating tumor cell invasion and migration has been demonstrated here. U87-MG, A549, and HT29 cell surfaces. A central loop and heparin-binding domain are required for the inhibitory process to occur, and antithrombin must be activated by heparin. This study has revealed a novel mechanism of inhibition for enteropeptidase, cleavage of antithrombin, in turn, has resulted in a molecule with antiangiogenic properties that reduces the formation of vascular endothelium.



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