Cenforce D is a medicine commonly used to treat two male sexual health conditions at the same time: Erectile dysfunction (ED) – difficulty getting or maintaining an erection. Premature ejaculation (PE) – ejaculating sooner than desired during sex. What it contains Cenforce D is a combination tablet with two active ingredients: Sildenafil – increases blood flow to the penis to help achieve an erection. Dapoxetine – a short-acting SSRI that helps delay ejaculation.